Distinct Antiviral Responses in Pluripotent versus Differentiated Cells
| dc.creator | Pare, Justin M. | en |
| dc.creator | Sullivan, Christopher S. | en |
| dc.date.accessioned | 2014-12-15T17:10:48Z | en |
| dc.date.available | 2014-12-15T17:10:48Z | en |
| dc.date.issued | 2014-02-06 | en |
| dc.description | Justin M. Pare, Christopher S. Sullivan, The University of Texas at Austin, Molecular Biosciences, Austin, Texas, United States of America | en |
| dc.description.abstract | There is a mystery unfolding, the solution of which has implications for the understanding of both stem cell biology and the evolution of the vertebrate pathogen defense response. At the heart of this puzzle lies the observation of substantially different antiviral responses in mammalian cells with high potency (e.g., embryonic stem, oocytes, induced pluripotent, teratocarcinoma, and embryonic carcinoma cells) versus differentiated somatic cells (i.e., epithelial, fibroblast, lymphocyte). While differentiated cells are proficient in the interferon (IFN)-associated protein-based response [1]–[3], pluripotent cells have an attenuated IFN response [4]–[8]. Conversely, pluripotent cells can utilize RNA interference (RNAi) to combat viruses [9], [10], while this response is attenuated in differentiated cells [11]. Here we provide an overview of this developing area of virology. | en |
| dc.description.catalogingnote | Email: chris_sullivan@austin.utexas.edu | en |
| dc.description.department | Molecular Biosciences | en |
| dc.description.sponsorship | This work was supported by grant RO1AI077746 from the National 201 Institutes of Health, a National Science Foundation Career Award, a Center for Cancer Research and Prevention in Texas grant, a Burroughs Wellcome Investigators in Pathogenesis Award, and a UT Austin Institute for Cellular and Molecular Biology fellowship to CSS. The funders had no role in the decision to publish, or preparation of the manuscript. | en |
| dc.identifier.Filename | journal.ppat.1003865.pdf | en |
| dc.identifier.citation | Pare JM, Sullivan CS (2014) Distinct Antiviral Responses in Pluripotent versus Differentiated Cells. PLoS Pathog 10(2): e1003865. doi:10.1371/journal.ppat.1003865 | en |
| dc.identifier.doi | DOI: 10.1371/journal.ppat.1003865 | en |
| dc.identifier.uri | http://hdl.handle.net/2152/27935 | en |
| dc.language.iso | English | en |
| dc.publisher | PLOS Pathogens | en |
| dc.rights | Administrative deposit of works to UT Digital Repository: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access at http://www.plospathogens.org. The public license is specified as CC-BY: http://creativecommons.org/licenses/by/4.0/. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University. | en |
| dc.subject | antivirals | en |
| dc.subject | cell differentiation | en |
| dc.subject | immune response | en |
| dc.subject | interferons | en |
| dc.subject | pluripotency | en |
| dc.subject | RNA interference | en |
| dc.subject | small interfering RNA | en |
| dc.subject | dsRNA ciruses | en |
| dc.title | Distinct Antiviral Responses in Pluripotent versus Differentiated Cells | en |
| dc.type | Article | en |
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