The functional network in predictive biology : predicting phenotype from genotype and predicting human disease from fungal phenotype
| dc.contributor.advisor | Marcotte, Edward M. | en |
| dc.creator | McGary, Kriston Lyle | en |
| dc.date.accessioned | 2011-01-25T20:34:38Z | en |
| dc.date.available | 2011-01-25T20:34:38Z | en |
| dc.date.issued | 2008-12 | en |
| dc.description | text | en |
| dc.description.abstract | The ability to predict is one of the hallmarks of successful theories. Historically, the predictive power of biology has lagged behind disciplines like physics because the biological world is complex, challenging to quantify, and full of exceptions. However, in recent years the amount of available data has expanded exponentially and biological predictions based on this data become a possibility. The functional gene network is a quantitative way to integrate this data and a useful framework for making biological predictions. This study demonstrates that functional networks capture real biological insight and uses the network to predict both subcellular protein localization and the phenotypic outcome of gene knockouts. Furthermore, I use the functional network to evaluate genetic modules shared between diverse organisms that lead to orthologous phenotypes, many that are non-obvious. I show that the successful predictions of the functional network have broad applicability and implications that range from the design of large-scale biological experiments to the discovery of genes with potential roles in human disease. | en |
| dc.description.department | Institute for Cellular and Molecular Biology | en |
| dc.format.medium | electronic | en |
| dc.identifier.uri | http://hdl.handle.net/2152/9708 | en |
| dc.language.iso | eng | en |
| dc.rights | Copyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works. | en |
| dc.subject | Biological predictions | en |
| dc.subject | Predictive biology | en |
| dc.subject | Phenotype | en |
| dc.subject | Genotype | en |
| dc.subject | Human disease | en |
| dc.title | The functional network in predictive biology : predicting phenotype from genotype and predicting human disease from fungal phenotype | en |
| thesis.degree.department | Cellular and Molecular Biology, Institute for | en |
| thesis.degree.discipline | Cell and Molecular Biology | en |
| thesis.degree.grantor | The University of Texas at Austin | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |