Aortic Medial Elastic Fiber Loss In Acute Ascending Aortic Dissection

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dc.contributor.utaustinauthorVowels, Travis Jamesen
dc.creatorRoberts, William Clifforden
dc.creatorVowels, Travis Jamesen
dc.creatorKitchens, Benjamin Leeen
dc.creatorKo, Jong Mien
dc.creatorFilardo, Giovannien
dc.creatorHenry, Albert Carlen
dc.creatorHamman, Baron Lloyden
dc.creatorMatter, Gregory Johnen
dc.creatorHebeler, Robert Fredericken
dc.date.accessioned2015-09-09T15:49:48Zen
dc.date.available2015-09-09T15:49:48Zen
dc.date.issued2011-12en
dc.description.abstractThe cause of acute aortic dissection continues to be debated. One school of thought suggests that underlying aortic medial cystic necrosis is the common denominator. The purpose of the present study was to determine if there was loss and, if so, how much loss of medial elastic fibers in the ascending aorta in patients with acute aortic dissection with the entrance tear in the ascending aorta. We examined operatively excised ascending aortas in 69 patients having acute dissection with tears in the ascending aorta. Patients with previous aortotomy, healed dissection, and connective tissue disorders were excluded. The 69 patients' ages ranged from 31 to 88 years (mean 56); 49 were men and 20 were women. Loss of aortic medial elastic fibers was graded as 0 (no loss), 1+ (trace), 2+ (mild), 3+ (moderate), and 4+ (full thickness loss). Of these 69 patients, 56 (82%) had 0 or 1+ elastic fiber loss; 13 patients (18%), 2+ to 4+ loss including 4 with 2+, 6 with 3+, and 2 with 4+. Nearly all patients (97%) had a history of systemic hypertension and/or had received antihypertensive drug therapy. In conclusion, most patients (82% in this study) having acute aortic dissection with entrance tears in the ascending aorta have normal numbers or only trace loss of aortic medial elastic fibers. Thus, underlying abnormal ascending aortic structure uncommonly precedes acute dissection. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;108:1639-1644)en
dc.description.departmentIntegrative Biologyen
dc.description.sponsorshipen
dc.identifier.citationWilliam Clifford Roberts, Travis James Vowelsa, Benjamin Lee Kitchensh, Jong Mi Ko, Giovanni Filardo, Albert Carl Henry, Baron Lloyd Hamman, Gregory John Matter, Robert Frederick Hebeler Jr. Aortic Medial Elastic Fiber Loss In Acute Ascending Aortic Dissection. The American Journal of Cardiology, Volume 108, Issue 11, (Dec. 2011) pp. 1639–1644. DOI: 10.1016/j.amjcard.2011.09.005en
dc.identifier.doi10.1016/j.amjcard.2011.09.005en
dc.identifier.issn0002-9149en
dc.identifier.urihttp://hdl.handle.net/2152/31030en
dc.identifier.urlen
dc.language.isoEnglishen
dc.relation.ispartofserialAmerican Journal of Cardiologyen
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.rights.holderen
dc.subjecta dissectionen
dc.subjectinternational registryen
dc.subjectclinical-featuresen
dc.subjectaneurysmen
dc.subjectexperienceen
dc.subjectvalveen
dc.subjectidiopathicaen
dc.subjectnecropsyen
dc.subjectnecrosisen
dc.subjectruptureen
dc.subjectcardiac & cardiovascular systemsen
dc.titleAortic Medial Elastic Fiber Loss In Acute Ascending Aortic Dissectionen
dc.typeArticleen

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