Inhaled Voriconazole For Prevention Of Invasive Pulmonary Aspergillosis

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dc.contributor.utaustinauthorTolman, Justin A.en
dc.contributor.utaustinauthorWiederhold, Nathan P.en
dc.contributor.utaustinauthorMcConville, Jason T.en
dc.contributor.utaustinauthorWilliams, Robert O.en
dc.creatorTolman, Justin A.en
dc.creatorWiederhold, Nathan P.en
dc.creatorMcConville, Jason T.en
dc.creatorNajvar, Laura K.en
dc.creatorBocanegra, Rosieen
dc.creatorPeters, Jay I.en
dc.creatorCoalson, Jacqueline J.en
dc.creatorGraybill, John R.en
dc.creatorPatterson, Thomas F.en
dc.creatorWilliams, Robert O.en
dc.date.accessioned2015-09-09T15:51:00Zen
dc.date.available2015-09-09T15:51:00Zen
dc.date.issued2009-06en
dc.description.abstractTargeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.en
dc.description.departmentPharmaceutical Sciencesen
dc.description.sponsorshipen
dc.identifier.citationTolman, J. A., Wiederhold, N. P., McConville, J. T., Najvar, L. K., Bocanegra, R., Peters, J. I., Williams, R. O. (Jun., 2009). Inhaled Voriconazole for Prevention of Invasive Pulmonary Aspergillosis. Antimicrobial Agents and Chemotherapy, 53(6), 2613–2615. doi:10.1128/AAC.01657-08en
dc.identifier.doi10.1128/aac.01657-08en
dc.identifier.issn0066-4804en
dc.identifier.urihttp://hdl.handle.net/2152/31157en
dc.identifier.urlen
dc.language.isoEnglishen
dc.relation.ispartofserialAntimicrobial Agents and Chemotherapyen
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.rights.holderen
dc.subjectmurine modelen
dc.subjectamphotericin-ben
dc.subjecttransplantationen
dc.subjectburdenen
dc.subjectmicrobiologyen
dc.subjectpharmacology & pharmacyen
dc.titleInhaled Voriconazole For Prevention Of Invasive Pulmonary Aspergillosisen
dc.typeArticleen

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