Dissolving and coated microneedles as useful drug delivery platforms

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dc.contributor.advisorWilliams, Robert O., III, 1956-
dc.contributor.advisorSmyth, Hugh D. C.
dc.creatorTarbox, Tamara Nina
dc.creator.orcid0000-0003-0678-0952
dc.date.accessioned2023-01-04T02:22:21Z
dc.date.available2023-01-04T02:22:21Z
dc.date.created2022-05
dc.date.issued2022-04-27
dc.date.submittedMay 2022
dc.date.updated2023-01-04T02:22:22Z
dc.description.abstractMicroneedles are a useful dosage form that combine key advantages of drug delivery by injection with advantages of transdermal drug delivery, while also overcoming some of the most notable limitations of these two therapeutic delivery modalities. Despite the potential utility of microneedles as a therapeutic dosage form, numerous challenges remain in satisfying the regulatory burden required to achieve FDA marketing approval. In Chapter 1, recent improvements in potentially scalable coating and manufacturing procedures for microneedles were reviewed. Advantages and limitations of certain types of microneedles, along with specific examples of manufacturing techniques were discussed, along with further improvements and regulatory considerations. In Chapter 2, an update on clinical development over the last five years including solid, coated, and dissolving microneedles was presented. Progress and results for selected clinical studies were discussed in detail.
dc.description.departmentPharmaceutical Sciences
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/117114
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/44008
dc.language.isoen
dc.subjectMicroneedles
dc.subjectHigh throughput
dc.subjectDissolving microneedles
dc.subjectCoated microneedles
dc.subjectInkjet printing
dc.subjectMicromolding
dc.subjectTherapeutic microneedles
dc.titleDissolving and coated microneedles as useful drug delivery platforms
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentPharmaceutical Sciences
thesis.degree.disciplinePharmaceutical Sciences
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Science in Pharmaceutical Sciences

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