Bacteria Use Type IV Pili to Walk Upright and Detach from Surfaces

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dc.creatorGibiansky, Maxsim L.
dc.creatorConrad, Jacinta C.
dc.creatorJin, Fan
dc.creatorGordon, Vernita D.
dc.creatorMotto, Dominick A.
dc.creatorMathewson, Margie A.
dc.date.accessioned2016-07-15T16:21:09Z
dc.date.available2016-07-15T16:21:09Z
dc.date.issued2010-10en
dc.description1. Department of Bioengineering, California Nano Systems Institute,University of California, Los Angeles, CA 90024, USA. 2. Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, USA. 3. Department of Materials Science and Engineering, University of Illinois, Urbana-Champaign, IL 61801, USA. 4. Department of Civil Engineering and Geological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.en_US
dc.description.abstractBacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili–driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and “walked” with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.en_US
dc.description.departmentCenter for Nonlinear Dynamicsen_US
dc.identifierdoi:10.15781/T25D8NF3X
dc.identifier.citationGibiansky, Maxsim L., Jacinta C. Conrad, Fan Jin, Vernita D. Gordon, Dominick A. Motto, Margie A. Mathewson, Wiktor G. Stopka, Daria C. Zelasko, Joshua D. Shrout, and Gerard CL Wong. "Bacteria use type IV pili to walk upright and detach from surfaces." Science 330, no. 6001 (2010): 197-197.en_US
dc.identifier.doi10.1126/science.1194238
dc.identifier.urihttp://hdl.handle.net/2152/39116
dc.language.isoengen_US
dc.publisherScienceen_US
dc.relation.ispartofUT Faculty/Researcher Worksen_US
dc.rights.restrictionOpenen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectbiofilmen_US
dc.subjectbacteria locomotionen_US
dc.titleBacteria Use Type IV Pili to Walk Upright and Detach from Surfacesen_US
dc.typeArticleen_US

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