Discovering Relations Between Mind, Brain, and Mental Disorders Using Topic Mapping

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dc.creatorPoldrack, Russell A.en
dc.creatorMumford, Jeanette A.en
dc.creatorSchonberg, Tomen
dc.creatorKalar, Donalden
dc.creatorBarman, Bishalen
dc.creatorYarkoni, Talen
dc.date.accessioned2013-06-28T15:58:09Zen
dc.date.available2013-06-28T15:58:09Zen
dc.date.issued2012-10-11en
dc.descriptionRussell A. Poldrack is with UT Austin, Jeanette A. Mumford is with UT Austin, Tom Schonberg is with UT Austin, Donald Kalar is with the NASA Ames Research Center, Bishal Barman is with UT Austin, Tal Yarkoni is with Colorado University.en
dc.description.abstractNeuroimaging research has largely focused on the identification of associations between brain activation and specific mental functions. Here we show that data mining techniques applied to a large database of neuroimaging results can be used to identify the conceptual structure of mental functions and their mapping to brain systems. This analysis confirms many current ideas regarding the neural organization of cognition, but also provides some new insights into the roles of particular brain systems in mental function. We further show that the same methods can be used to identify the relations between mental disorders. Finally, we show that these two approaches can be combined to empirically identify novel relations between mental disorders and mental functions via their common involvement of particular brain networks. This approach has the potential to discover novel endophenotypes for neuropsychiatric disorders and to better characterize the structure of these disorders and the relations between them.en
dc.description.departmentPsychologyen
dc.description.sponsorshipThis work was supported by NIH grant RO1MH082795 (to RAP) and F32NR012081 (to TY) and by the Texas Emerging Technology Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationPoldrack RA, Mumford JA, Schonberg T, Kalar D, Barman B, et al. (2012) Discovering Relations Between Mind, Brain, and Mental Disorders Using Topic Mapping. PLoS Comput Biol 8(10): e1002707. doi:10.1371/journal.pcbi.1002707en
dc.identifier.doi10.1371/journal.pcbi.1002707en
dc.identifier.urihttp://hdl.handle.net/2152/20564en
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.rightsCC-BYen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.subjectAutismen
dc.subjectCognitionen
dc.subjectCognitive neurologyen
dc.subjectCognitive neuroscienceen
dc.subjectCognitive psychologyen
dc.subjectEmotionsen
dc.subjectMemoryen
dc.subjectSchizophreniaen
dc.titleDiscovering Relations Between Mind, Brain, and Mental Disorders Using Topic Mappingen
dc.typeArticleen

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