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dc.creatorChampredon, Daviden_US
dc.creatorBellan, Steven E.en_US
dc.creatorDelva, Wimen_US
dc.creatorHunt, Spenceren_US
dc.creatorShi, Chyun-Fungen_US
dc.creatorSmieja, Mareken_US
dc.creatorDushoff, Jonathanen_US
dc.date.accessioned2016-10-28T19:53:19Z
dc.date.available2016-10-28T19:53:19Z
dc.date.issued2015-06en_US
dc.identifierdoi:10.15781/T23775Z0P
dc.identifier.citationChampredon, David, Steven E. Bellan, Wim Delva, Spencer Hunt, Chyun-Fung Shi, Marek Smieja, and Jonathan Dushoff. "The effect of sexually transmitted co-infections on HIV viral load amongst individuals on antiretroviral therapy: a systematic review and meta-analysis." BMC infectious diseases, Vol. 15, No. 1 (Jun., 2015): 1.en_US
dc.identifier.issn1471-2334en_US
dc.identifier.urihttp://hdl.handle.net/2152/43338
dc.description.abstractAntiretroviral therapy (ART) markedly reduces HIV transmission, and testing and treatment programs have been advocated as a method for decreasing transmission at the population level. Little is known, however, about the extent to which sexually transmitted infections (STIs), which increase the HIV infectiousness of untreated individuals, may decrease the effectiveness of treatment as prevention. Methods: We searched major bibliographic databases to August 12th, 2014 and identified studies reporting differences in HIV transmission rate or in viral load between individuals on ART who either were or were not co-infected with another STI. We used hierarchical Bayesian models to estimate viral load differences between individuals with and without STI co-infections. Results: The search strategy retrieved 1630 unique citations of which 14 studies (reporting on 4607 HIV viral load measurements from 2835 unique individuals) met the inclusion criteria. We did not find any suitable studies that estimated transmission rates directly in both groups. Our meta-analysis of HIV viral load measurements among treated individuals did not find a statistically significant effect of STI co-infection; viral loads were, on average, 0.11 log10 (95 % CI -0.62 to 0.83) higher among co-infected versus non-co-infected individuals. Conclusions: Direct evidence about the effects of STI co-infection on transmission from individuals on ART is very limited. Available data suggests that the average effect of STI co-infection on HIV viral load in individuals on ART is less than 1 log10 difference, and thus unlikely to decrease the effectiveness of treatment as prevention. However, there is not enough data to rule out the possibility that particular STIs pose a larger threat.en_US
dc.description.sponsorshipJames S. McDonnell Foundationen_US
dc.description.sponsorshipCanadian Institutes of Health Researchen_US
dc.description.sponsorshipCanadian Natural Sciences and Engineering Research Councilen_US
dc.description.sponsorshipNational Institute of General Medical Sciences (Models of Infectious Disease Agent Studyen_US
dc.language.isoEnglishen_US
dc.relation.ispartofen_US
dc.rightsAdministrative deposit of works to Texas ScholarWorks: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access or the publisher allows a PDF version of the article to be freely posted online. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en_US
dc.subjectfemale genital-tracten_US
dc.subjectseminal plasmaen_US
dc.subjectbacterial vaginosisen_US
dc.subjectdrugen_US
dc.subjectconcentrationsen_US
dc.subjectdiscordant-couplesen_US
dc.subjectinfected menen_US
dc.subjecttype-1 rnaen_US
dc.subjectcellen_US
dc.subjectcounten_US
dc.subjecttransmissionen_US
dc.subjecturethritisen_US
dc.subjectinfectious diseasesen_US
dc.titleThe Effect of Sexually Transmitted Co-Infections on HIV Viral Load Amongst Individuals on Antiretroviral Therapy: A Systematic Review and Meta-Analysisen_US
dc.typeArticleen_US
dc.description.departmentCenter for Computational Biology and Bioinformaticsen_US
dc.rights.restrictionOpenen_US
dc.identifier.doi10.1186/s12879-015-0961-5en_US
dc.contributor.utaustinauthorBellan, Steven E.en_US
dc.relation.ispartofserialBMC Infectious Diseasesen_US


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