Effect of peg-ylated fibrin gel injections on functional recovery of skeletal muscle following ischemia/reperfusion injury

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dc.contributor.advisorFarrar, Roger P.
dc.creatorFegan, Kelly Marie, 1983-
dc.date.accessioned2017-01-23T16:01:33Z
dc.date.available2017-01-23T16:01:33Z
dc.date.issued2007-05
dc.description.abstractIschemia/Reperfusion (I/R) injury can cause irreversible damage to muscle tissue. Injection of a biomaterial, such as PEG-ylated fibrin gel, with the capability to release growth factors in a time dependent manner has the potential to increase recovery of muscle tissue following an I/R injury. In this study, we examined the effects of PEGylated fibrin gel on muscle tissue following I/R injury. Following tourniquet application, there was no significant difference in force recovery between injection and non-injection groups for the In Vivo force assessment (p=0.19), the In Situ force assessment (p=0.12), and the Specific tetanic tension of the muscle tissue (p=0.51). These results indicate that PEG-ylated fibrin gel has no detrimental effect on muscle tissue when injected, making it an appropriate material for injection into muscle tissue for the release of growth factors.en_US
dc.description.departmentKinesiology and Health Educationen_US
dc.format.mediumelectronicen_US
dc.identifierdoi:10.15781/T27S7HW34
dc.identifier.urihttp://hdl.handle.net/2152/44483
dc.language.isoengen_US
dc.relation.ispartofUT Electronic Theses and Dissertationsen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.rights.restrictionRestricteden_US
dc.subjectIschemia/Reperfusion (I/R) injuryen_US
dc.subjectMuscle tissue damageen_US
dc.subjectPEG-ylated fibrin gelen_US
dc.titleEffect of peg-ylated fibrin gel injections on functional recovery of skeletal muscle following ischemia/reperfusion injuryen_US
dc.typeThesisen_US
dc.type.genreThesisen_US
thesis.degree.departmentKinesiology and Health Educationen_US
thesis.degree.disciplineKinesiologyen_US
thesis.degree.grantorUniversity of Texas at Austinen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Artsen_US

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