Transition metal- and organo-catalyzed cycloreductions, cycloadditions and cycloisomerizations
| dc.contributor.advisor | Krische, Michael J. | |
| dc.creator | Luis, Ana Liza | en |
| dc.date.accessioned | 2015-04-28T16:57:13Z | en |
| dc.date.available | 2015-04-28T16:57:13Z | en |
| dc.date.issued | 2005-12 | en |
| dc.description | text | en |
| dc.description.abstract | The catalytic activation of enones in C-C bond forming processes represents a promising alternative to the prefabrication of chemically labile enols and enolates. Through the use of a (diketonato)cobalt/silane catalyst system, we have devised highly diastereoselective aldol and Michael cycloreductions (J. Am. Chem. Soc. 2001, 123, 5112). Modulation of the catalyst system has enabled the first intramolecular metal-catalyzed alkene (2+2)cycloaddition (J. Am. Chem. Soc. 2001, 123, 6716). Finally, the concept of catalytic nucleophilic enone activation embodied by the Morita-Baylis- Hillman and Rauhut Currier reactions has been utilized to develop an organic catalyst system for the cycloisomerization of bis-enones, i.e. an intramolecular Rauhut Currier reaction (J. Am. Chem. Soc. 2002, 124, 2402). Notably, this protocol allowed for the selective "crossed" cyclization of unsymmetrical bis-enone substrates. | en |
| dc.description.department | Chemistry | en |
| dc.format.medium | electronic | en |
| dc.identifier.uri | http://hdl.handle.net/2152/29634 | en |
| dc.language.iso | eng | en |
| dc.rights | Copyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works. | en |
| dc.subject | Transition metals | en |
| dc.subject | Organo-catalyzed cycloreductions | en |
| dc.subject | Organo-catalyzed cycloadditions | en |
| dc.subject | Organo-catalyzed cycloisomerizations | en |
| dc.subject | C-C bond | en |
| dc.subject | Enones | en |
| dc.subject | Cycloisomerization of bis-enones | en |
| dc.title | Transition metal- and organo-catalyzed cycloreductions, cycloadditions and cycloisomerizations | en |
| dc.type | Thesis | en |
| thesis.degree.department | Chemistry | en |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | The University of Texas at Austin | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |