Microencapsulation process

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorGeorge W. Cuff
dc.creatorJames W. McGinity
dc.date.accessioned2019-10-23T21:44:29Z
dc.date.available2019-10-23T21:44:29Z
dc.date.filed1983-09-15
dc.date.issued1985-05-21
dc.description.abstractNylon coated microcapsules containing hydrophilic solvent-soluble anionic, cationic or quaternary drug salts were prepared by interfacial polycondensation techniques. In a first stage, the drug substance to be encapsulated is dissolved in an aqueous phase. Examples of drugs encapsulated are morphine sulfate, diphenhydramine hydrochloride, and methantheline bromide. Next the aqueous drug solution is dispersed in an organic phase. In a second stage complementary polycondensation reactants each in an organic phase are added separately, either sequentially or simultaneously, to the dispersion prepared in the first stage. Microcapsules of nylon form around the hydrophilic solvent soluble core drug substance.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber6532458
dc.identifier.patentnumber4518547
dc.identifier.urihttps://hdl.handle.net/2152/77297
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/4386
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K9/50
dc.subject.cpcB01J13/16
dc.subject.uspc252/408.1
dc.subject.uspc264/4.7
dc.subject.uspc424/497
dc.subject.uspc514/282
dc.subject.uspc8/526
dc.titleMicroencapsulation process
dc.typePatent

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