Effects of stress conditions on Wangiella dermatitidis and its various chitin synthase mutants

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dc.contributor.advisorSzaniszlo, Paul J.en
dc.creatorNiu, Weien
dc.date.accessioned2015-12-16T19:50:59Zen
dc.date.available2015-12-16T19:50:59Zen
dc.date.issued2006-08en
dc.descriptiontexten
dc.description.abstractWangiella dermatitidis is a dematiaceous (melanized) fungus that causes pheohyphomycosis in humans. Although W. dermatitidis predominantly exists as a budding yeast in vitro, it can be induced to convert into one or the other of its alternative morphotypes by culture under different growth conditions, including those considered to be stress conditions. Five different Wangiella chitin synthesis structural genes (WdCHS) have been identified, and mutants (wdchs[Delta symbol]) have been derived with each individual WdCHS gene and all combinations of two WdCHS genes disrupted. Although some of their phenotypic characteristics under different temperatures and stress conditions have been studied, a complete review of the phenotypic differences between the Wangiella wild-type strain and the wdchs[Delta symbol] mutant strains grown side-by-side and subjected simultaneously to the various stress conditions investigated has not been carried out. The aim of this thesis is to compare the stress-induced phenotypic changes exhibited among the Wangiella strains investigated to provide clues for future research.en
dc.description.departmentMicrobiologyen
dc.format.mediumelectronicen
dc.identifierdoi:10.15781/T2BK9Fen
dc.identifier.urihttp://hdl.handle.net/2152/32718en
dc.language.isoengen
dc.relation.ispartofUT Electronic Theses and Dissertationsen
dc.rightsCopyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en
dc.rights.restrictionRestricteden
dc.subjectPheohyphomycosisen
dc.subjectDematiaceous fungusen
dc.subjectMelanized fungusen
dc.titleEffects of stress conditions on Wangiella dermatitidis and its various chitin synthase mutantsen
dc.typeThesisen
dc.type.genreThesisen
thesis.degree.departmentMicrobiologyen
thesis.degree.disciplineMicrobiologyen
thesis.degree.grantorThe University of Texas at Austinen
thesis.degree.levelMastersen
thesis.degree.nameMaster of Artsen

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