Nanoparticles formed by anti-solvent precipitation to produce redispersible and amorphous drug powders

Simple item page
dc.contributor.advisorJohnston, Keith P., 1955-
dc.creatorPaguio, Joseph Corpus
dc.date.accessioned2017-07-13T15:01:47Z
dc.date.available2017-07-13T15:01:47Z
dc.date.issued2007-05
dc.description.abstractAnti-solvent precipitation produced sub-100 nm [Greek small letter beta]-carotene (BCN) particles despite only modest mixing energy. The particles were stabilized with poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (P407) and/or hydroxypropylmethylcellulose (HPMC E5) to increase the time scale for coagulation relative to the mixing time. However, this method could only produce itraconazole (ITZ) particles in the 250-300 nm range. The higher solubility of ITZ versus BCN promoted solute diffusion and thus, facilitated growth by Ostwald ripening. Anti-solvent precipitation was then used to produce nanoparticle suspensions of poorly water-soluble drugs in an amorphous state. The nanoparticles were recovered by flocculation with sodium sulfate, filtered and dried to form redispersible powders. The redispersed ITZ particle size of 300 nm and naproxen (NAP) particle size of 600 nm were comparable to the values in the aqueous suspension prior to flocculation, and consistent with primary particles observed by SEM. Dissolution of ITZ and danazol (DAN) particles in basic media yielded high supersaturation levels up to 16.9 times the ITZ equilibrium solubility or 5.9 times the DAN equilibrium solubility. The flocculated powders had calculated 4-hr areas under the curve (AUCs) 1.5-6 times higher than their lyophilized counterparts. The ability to produce and recover potent amorphous nanoparticles and to demonstrate these nanoparticles can generate high levels of supersaturation offer new opportunities for improving bioavailability of poorly water-soluble drugs.en_US
dc.description.departmentChemical Engineeringen_US
dc.format.mediumelectronicen_US
dc.identifierdoi:10.15781/T2Q52FT5M
dc.identifier.urihttp://hdl.handle.net/2152/60405
dc.language.isoengen_US
dc.relation.ispartofUT Electronic Theses and Dissertationsen_US
dc.rightsCopyright © is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works.en_US
dc.rights.restrictionRestricteden_US
dc.subjectAnti-solvent precipitationen_US
dc.subjectNanoparticlesen_US
dc.subjectNon-water soluble drugsen_US
dc.titleNanoparticles formed by anti-solvent precipitation to produce redispersible and amorphous drug powdersen_US
dc.typeThesisen_US
dc.type.genreThesisen_US
thesis.degree.departmentChemical Engineeringen_US
thesis.degree.disciplineChemical Engineeringen_US
thesis.degree.grantorUniversity of Texas at Austinen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Scienceen_US

Access full-text files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
txu-oclc-259717259.pdf
Size:
502.58 KB
Format:
Adobe Portable Document Format
Description:
Access restricted to UT Austin EID holders
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.66 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UT Electronic Theses and Dissertations