Determining enantiomeric excess using indicator-displacement assays

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorAnslyn, Eric V.
dc.creatorZhu, Lei
dc.creatorFolmer-Andersen, J. Frantz
dc.date.accessioned2019-10-23T19:26:46Z
dc.date.available2019-10-23T19:26:46Z
dc.date.filed2005-01-14
dc.date.issued2008-02-19
dc.description.abstractThe invention includes an enantioselective indicator-displacement assay useful to determine enantiomeric excess (ee) enantiomeric samples calorimetrically. Determination may be by inspection of color with the naked eye, spectrographic measurement, or mathematical calculation. Concentration may also be determined. The assay may involve two independent absorption measurements. On suitable group of enantiomeric molecules to be assayed include α-hydroxyacids. The inherent relationship between the absorbance of the indicator-displacement ensemble and the overall concentration and ee of the analyte is established through solution equilibria. The invention also includes use of the assay in drug screening and manufacturing, high throughput screening of catalysts and kits for use in conducting assays of the invention.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber11036642
dc.identifier.patentnumber7332343
dc.identifier.urihttps://hdl.handle.net/2152/76872
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3961
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcG01N33/542
dc.subject.uspc435/7.92
dc.subject.uspc435/7.93
dc.subject.uspc436/86
dc.subject.uspc544/218
dc.subject.uspc548/439
dc.titleDetermining enantiomeric excess using indicator-displacement assays
dc.typePatent

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