Texaphyrin complexes having improved functionalization

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dc.contributor.assigneePharmacyclics, Inc.
dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorJonathan L. Sessler
dc.creatorGregory W. Hemmi
dc.creatorTarak D. Mody
dc.date.accessioned2019-10-23T14:31:34Z
dc.date.available2019-10-23T14:31:34Z
dc.date.filed1995-06-06
dc.date.issued1997-01-07
dc.description.abstractTexaphyrin metal complexes having improved functionalization include the addition of electron-donating groups to positions 2, 7, 12, 15, 18 and/or 21 and/or the addition of electron-withdrawing groups to positions 15 and/or 18 of the macrocycle. Electron-donating groups at positions 2, 7, 12, 15, 18 and/or 21 contribute electrons to the aromatic .pi. system of the macrocycle which stabilizes the metal complex to demetallation and the imine bonds to hydrolysis. These texaphyrin metal complexes having enhanced stability are useful for localization, radiosensitization and radiation therapy. Electron-withdrawing groups at positions 15 and/or 18 render the macrocycle more readily reduced, i.e. the redox potential is lower and the macrocycle more readily gains an electron to form a radical. Such texaphyrins having a low redox potential are useful for radiation sensitization applications.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber8468209
dc.identifier.patentnumber5591422
dc.identifier.urihttps://hdl.handle.net/2152/76635
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3724
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K41/0038
dc.subject.cpcA61K41/0076
dc.subject.cpcC07D487/18
dc.subject.cpcC07D487/22
dc.subject.uspc424/9.362
dc.subject.uspc424/1.65
dc.subject.uspc424/9.361
dc.subject.uspc534/10
dc.subject.uspc534/15
dc.subject.uspc540/472
dc.subject.uspc540/474
dc.titleTexaphyrin complexes having improved functionalization
dc.typePatent

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