Cu-catalyzed three-component carboamination of 2-arylacrylates

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dc.contributor.advisorHull, Kami
dc.creatorPopov, Andrei
dc.date.accessioned2022-01-21T15:32:39Z
dc.date.available2022-01-21T15:32:39Z
dc.date.created2021-08
dc.date.issued2021-08
dc.date.submittedAugust 2021
dc.date.updated2022-01-21T15:32:41Z
dc.description.abstractThere is an increasing demand for modern methods to construct one of the most ubiquitous bonds in biologically active molecules: a carbon-nitrogen bond. Transition metal catalysis represents a powerful tool to create new chemical bonds with great efficiency and selectivity. Thus, the development of novel catalytic techniques, based on transitions metals, for quick and effective assembly of nitrogen-containing organic molecules can be an advancement in synthetic routes to many drug molecules, agrochemicals, functional materials and many others. 1,2-carboamination of alkenes is the approach that unlocks the access to rapid assembly of complex organic nitrogen-containing frameworks from readily available feedstocks. In particular, the carboamination of acrylates can provide a synthetic access to various aminoacid derivatives. The present thesis is devoted to the development of the Cu-catalyzed carboamination of 2-arylacrylates. A wide substrate scope with good functional group tolerance is demonstrated. The mechanistic aspects of the reaction are discussed.
dc.description.departmentChemistry
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/94781
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/21698
dc.language.isoen
dc.subjectChemistry
dc.subjectCatalysis
dc.subjectOrganic synthesis
dc.subjectTransition metal catalysis
dc.subjectCarboamination
dc.titleCu-catalyzed three-component carboamination of 2-arylacrylates
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentChemistry
thesis.degree.disciplineChemistry
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelMasters
thesis.degree.nameMaster of Arts

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