Nanosystems for combined therapy and imaging of pancreatic cancer

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dc.contributor.advisorBrannon-Peppas, Lisa, 1962-en
dc.contributor.advisorEmelianov, Stanislav Y.en
dc.contributor.committeeMemberMcGinity, Jamesen
dc.contributor.committeeMemberTunnell, Jamesen
dc.contributor.committeeMemberStevenson, Keithen
dc.contributor.committeeMemberBrown, Richarden
dc.contributor.committeeMemberSokolov, Konstantinen
dc.creatorHoman, Kimberly Annen
dc.date.accessioned2011-01-24T21:57:21Zen
dc.date.available2011-01-24T21:57:21Zen
dc.date.available2011-01-24T21:58:25Zen
dc.date.issued2010-12en
dc.date.submittedDecember 2010en
dc.date.updated2011-01-24T21:58:25Zen
dc.descriptiontexten
dc.description.abstractPancreatic cancer remains a major unsolved health problem, with conventional cancer treatments having little impact on disease course. The objective of this thesis is to create innovative tools to better understand and improve chemotherapeutic treatment of pancreatic cancer. Towards this end, nanosystems were designed with a dual purpose: to carry chemotherapeutic drugs and act as photoacoustic imaging contrast agents. The overarching hypothesis is that these nanosystems can provide enhanced therapy for pancreatic cancer and enable visualization of drug delivery. Demonstrated in this dissertation is the design, synthesis, and characterization of two such nanosystems built to carry the chemotherapeutic agent gemcitabine while acting as a photoacoustic imaging contrast agent. The nanosystems were also shown to be multifunctional with possible application as photothermal therapy agents and cellular functional sensors. Although future research is required to fully investigate the clinical potential of these systems for pancreatic cancer, the work presented in this dissertation is a step towards creation of multifunctional nanosystems that will enable non-invasive, in vivo photoacoustic imaging of drug delivery.en
dc.description.departmentBiomedical Engineeringen
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttp://hdl.handle.net/2152/ETD-UT-2010-12-2261en
dc.language.isoengen
dc.subjectNanosystemsen
dc.subjectNanoparticlesen
dc.subjectPhotoacousticsen
dc.subjectDrug deliveryen
dc.subjectChemotherapyen
dc.subjectNanocagesen
dc.subjectNanoplatesen
dc.subjectPancreatic canceren
dc.titleNanosystems for combined therapy and imaging of pancreatic canceren
dc.type.genrethesisen
thesis.degree.departmentBiomedical Engineeringen
thesis.degree.disciplineBiomedical Engineeringen
thesis.degree.grantorUniversity of Texas at Austinen
thesis.degree.levelDoctoralen
thesis.degree.nameDoctor of Philosophyen

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