Methods and compositions for modulation and inhibition of telomerase in vitro
dc.contributor.assignee | CTRC Research Foundation | |
dc.contributor.assignee | Board of Regents, The University of Texas System | |
dc.creator | Shih-Fong Chen | |
dc.creator | Bradford E. Windle | |
dc.creator | Blain M. Mamiya | |
dc.creator | Terace M. Fletcher | |
dc.creator | Ira Maine | |
dc.creator | Sean M. Kerwin | |
dc.creator | Makoto Wajima | |
dc.creator | Miguel Salazar | |
dc.date.accessioned | 2019-10-23T21:40:32Z | |
dc.date.available | 2019-10-23T21:40:32Z | |
dc.date.filed | 1996-07-03 | |
dc.date.issued | 2000-04-25 | |
dc.description.abstract | It was found that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells produce a processive telomerase activity. Nucleotide analogs, such as 7-deaza-2'-deoxyquanosine-5'-triphosphate (7-deaza-dGTP) were found to be substrates for processive telomerase and incorporated into telomeric sequence. The incorporation of this nucleotide subsequently affected the processivity of telomerase, converting processive telomerase to non-processive telomerase. The incorporation of this nucleotide analogs was also found to inhibit formation of G-quartets by telomeric sequence. Other methods for converting cancer processive telomerase to the more benign non-processive telomerase include partially cleaving the telomerase RNA. The nucleoside analogs were found to be capable of a variety of activities including mediating allosteric-like inhibition of telomerase, premature termination and shortening of telomeric DNA, destabilization of telomeric structure and function and eventually cell death. Understanding the mechanisms of telomerase modulation by the 7-deaza-nucleotides has allowed the design of new telomerase inhibitors, modulators and agents for affecting telomere structure and function. These discoveries have application in the treatment of cancer. | |
dc.description.department | Board of Regents, University of Texas System | |
dc.identifier.applicationnumber | 8675119 | |
dc.identifier.patentnumber | 6054442 | |
dc.identifier.uri | https://hdl.handle.net/2152/77233 | |
dc.identifier.uri | http://dx.doi.org/10.26153/tsw/4322 | |
dc.publisher | United States Patent and Trademark Office | |
dc.relation.ispartof | University of Texas Patents | |
dc.relation.ispartof | University of Texas Patents | |
dc.rights.restriction | Open | |
dc.rights.restriction | Open | |
dc.subject.cpc | A61K31/7076 | |
dc.subject.cpc | A61K31/7064 | |
dc.subject.cpc | A61K31/7068 | |
dc.subject.cpc | A61K31/7072 | |
dc.subject.cpc | A61K31/708 | |
dc.subject.cpc | C07H19/14 | |
dc.subject.uspc | 435/6.12 | |
dc.subject.uspc | 514/45 | |
dc.subject.uspc | 514/46 | |
dc.subject.uspc | 514/47 | |
dc.subject.uspc | 514/48 | |
dc.subject.uspc | 514/49 | |
dc.subject.uspc | 514/50 | |
dc.subject.uspc | 514/51 | |
dc.subject.uspc | 536/26.26 | |
dc.subject.uspc | 536/27.12 | |
dc.subject.uspc | 536/27.2 | |
dc.subject.uspc | 536/27.8 | |
dc.subject.uspc | 536/27.81 | |
dc.title | Methods and compositions for modulation and inhibition of telomerase in vitro | |
dc.type | Patent |
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