T7 RNA polymerase variants with expanded substrate range and enhanced transcriptional yield

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dc.contributor.assigneeThe Board of Regents of the University of Texas System
dc.creatorAndrew D. Ellington
dc.creatorAdam J. Meyer
dc.date.accessioned2019-10-23T14:06:48Z
dc.date.available2019-10-23T14:06:48Z
dc.date.filed2015-03-20
dc.date.issued2018-06-05
dc.description.abstractDisclosed are T7 RNA polymerase variants with enhanced transcriptional activity. T7 RNA polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing RNA molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants with broad substrate range.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber15127617
dc.identifier.patentnumber9988612
dc.identifier.urihttps://hdl.handle.net/2152/76499
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3588
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcC12N9/1247
dc.subject.cpcC12N15/111
dc.subject.cpcC12N15/115
dc.subject.cpcC12P19/34
dc.subject.cpcC12Y207/07006
dc.subject.cpcC12N2310/141
dc.subject.cpcC12N2310/16
dc.subject.cpcC12N2320/51
dc.subject.cpcC12N2330/00
dc.subject.cpcC12N2330/51
dc.titleT7 RNA polymerase variants with expanded substrate range and enhanced transcriptional yield
dc.typePatent

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