Towards peptide-binding peptides
| dc.contributor.advisor | Anslyn, Eric V., 1960- | en |
| dc.contributor.advisor | Kodadek, Thomas J. | en |
| dc.creator | Zhang, Zhiwen | en |
| dc.date.accessioned | 2011-04-14T17:05:36Z | en |
| dc.date.available | 2011-04-14T17:05:36Z | en |
| dc.date.issued | 2001-08 | en |
| dc.description | text | en |
| dc.description.abstract | Peptide-binding peptides can be a very powerful research tool. A novel methodology, based on the mechanism of bacteriophage l switch in E. coli and combinatorial screening, has been developed to isolate peptides that bind another target peptide in vivo. Two pairs of interacting peptides have been isolated and characterized. One of the potential applications of such peptide-binding peptides is to be utilized as protein purification tags. Another novel aspect of this research is that a candidate peptide is able to inhibit an enzyme-catalyzed protein hydrolysis by binding specifically to a peptide sequence on the substrate which is recognized by the protease. In other words, a novel concept of substrate-directed enzyme inhibitors has been developed. | |
| dc.description.department | Chemistry and Biochemistry | en |
| dc.format.medium | electronic | en |
| dc.identifier.uri | http://hdl.handle.net/2152/10911 | en |
| dc.language.iso | eng | en |
| dc.rights | Copyright is held by the author. Presentation of this material on the Libraries' web site by University Libraries, The University of Texas at Austin was made possible under a limited license grant from the author who has retained all copyrights in the works. | en |
| dc.rights.restriction | Restricted | en |
| dc.subject | Peptides | en |
| dc.subject | Protein binding | en |
| dc.title | Towards peptide-binding peptides | en |
| thesis.degree.department | Chemistry and Biochemistry | en |
| thesis.degree.discipline | Chemistry | en |
| thesis.degree.grantor | The University of Texas at Austin | en |
| thesis.degree.level | Doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |
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