Hot-melt extrusion of modified release multi-particulates

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorJames W. McGinity
dc.creatorSandra U. Schilling
dc.date.accessioned2019-10-23T14:33:29Z
dc.date.available2019-10-23T14:33:29Z
dc.date.filed2009-08-20
dc.date.issued2015-11-24
dc.description.abstractThe present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates into a polymeric or wax-like matrix. The modified release multi-particulates comprise an effective amount of a therapeutic compound having a known or desired drug-release profile. Modified release multi-particulates may include a polymeric coat or may be incorporated into particle or core material. The polymer matrix comprises a thermoplastic polymer or lipophilic carrier or a mixture thereof that softens or melts at elevated temperature and allows the distribution of the modified release multi-particulates in the polymer matrix during thermal processing. Formulation compounds and processing conditions are selected in a manner to preserve the controlled release characteristics and/or drug-protective properties of the original modified release multi-particulates.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber12544963
dc.identifier.patentnumber9192578
dc.identifier.urihttps://hdl.handle.net/2152/76699
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3788
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K9/2077
dc.subject.cpcA61K9/1641
dc.subject.cpcA61K9/1694
dc.subject.cpcA61K9/2081
dc.subject.cpcA61K31/522
dc.subject.cpcB29C48/05
dc.subject.cpcB29C48/00
dc.subject.cpcB29K2105/0035
dc.subject.uspcNo longer published
dc.titleHot-melt extrusion of modified release multi-particulates
dc.typePatent

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