Measurement of neural functionality using phase sensitive optical coherence reflectometry

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorMilner, Thomas E.
dc.creatorDave, Digant P.
dc.creatorAkkin, Taner
dc.creatorRylander III, H. Grady
dc.date.accessioned2019-10-23T14:01:53Z
dc.date.available2019-10-23T14:01:53Z
dc.date.filed2010-03-04
dc.date.issued2013-01-08
dc.description.abstractOptical methods, devices, and systems for noninvasively detecting transient surface displacements in a neuron are disclosed. Methods, devices, and systems provided may employ a phase-sensitive optical low coherence reflectometer. In addition, surface displacements due to action potential propagation in neural tissues may be detected in some embodiments using back-reflected light. According to some embodiments, exogenous chemicals or reflect ion coatings are not required. Transient neural surface displacement of less then 1 nm in amplitude and 1 ms in duration may be detected and may be generally coincident with action potential arrival to the optical measurement site. The systems and methods may be used for noninvasive detection of various neuropathies such as retinal neuropathies. They may also be useful in detecting the effects of various pharmacological agents.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber12717735
dc.identifier.patentnumber8352022
dc.identifier.urihttps://hdl.handle.net/2152/76367
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3456
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61B5/0059
dc.subject.cpcA61B3/102
dc.subject.cpcA61B5/0066
dc.subject.cpcA61B3/1225
dc.subject.cpcG01N21/4795
dc.subject.cpcG01N2021/1782
dc.subject.uspc600/544
dc.subject.uspc600/407
dc.titleMeasurement of neural functionality using phase sensitive optical coherence reflectometry
dc.typePatent

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