Effective hormonal peptides: D-3-Pal.sup.6 -LHRH

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dc.contributor.assigneeBoard of Regents, Univ. of Tex. Sys.
dc.creatorFolkers, Karl A.
dc.creatorBowers, Cyril Y.
dc.creatorJie-Cheng, Xu
dc.date.accessioned2019-05-14T14:36:14Z
dc.date.available2019-05-14T14:36:14Z
dc.date.filed1987-02-10
dc.date.issued1987-02-10
dc.description.abstractTwo sets of hormonal peptides are synthesized which are super agonists of the luteinizing hormone releasing hormone (LHRH). Chronic administration results in the inhibition of LHRH which is responsible for stimulating cell growth in the testes. One peptide has the D(dextro)-form of a monoheterocyclic amino acid in position six (D-3-pyridyl-alanine) while the other peptide has a bi-heterocyclic amino acid in that same position (.beta.-(3-quinolyl)-D-.alpha.-alanine. Both peptides are less metabolically reactive than those in the prior art and yet both peptides are significantly more potent than LHRH itself.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber6727711
dc.identifier.patentnumber4642332
dc.identifier.urihttps://hdl.handle.net/2152/74729
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1847
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.subject.cpcA61K38/00
dc.subject.cpcC07K7/23
dc.subject.cpcY10S930/13
dc.subject.uspc530/313
dc.subject.uspc930/20
dc.subject.uspc930/21
dc.subject.uspc930/130
dc.subject.uspc930/DIG696
dc.subject.uspc930/DIG698
dc.titleEffective hormonal peptides: D-3-Pal.sup.6 -LHRH
dc.typePatent

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