Methods for treating bone deficit conditions with benzothiazole

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dc.contributor.assigneeOsteoScreen
dc.contributor.assigneeZymo Genetics, Inc.
dc.contributor.assigneeTHE UNIVERSITY OF TEXAS SYSTEM
dc.creatorPetrie, Charles R. III
dc.creatorOrme, Mark W.
dc.creatorMundy, Gregory R.
dc.creatorBaindur, Nand
dc.creatorRobbins, Kirk G.
dc.creatorHurley, Laurence H.
dc.creatorKerwin, Sean M.
dc.date.accessioned2019-05-14T14:34:52Z
dc.date.available2019-05-14T14:34:52Z
dc.date.filed1999-07-13
dc.date.issued1999-07-13
dc.description.abstract" Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or ""linker"" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 .ANG., are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems. "
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber8808742
dc.identifier.patentnumber5922753
dc.identifier.urihttps://hdl.handle.net/2152/74676
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1794
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.subject.cpcA61K31/428
dc.subject.cpcA61K31/4184
dc.subject.uspc514/447
dc.subject.uspc514/430
dc.subject.uspc514/439
dc.subject.uspc514/443
dc.titleMethods for treating bone deficit conditions with benzothiazole
dc.typePatent

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