Method of phosphate ester hydrolysis
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Date
1998-06-09
Authors
Richard A. Miller
William C. Dow
Jonathan L. Sessler
Meredith Wright
Darren Magda
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.