Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor
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Date
2005-02-15
Authors
Carney, Darrell H.
Crowther, Roger S.
Stiernberg, Janet
Bergmann, John S.
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.