Browsing by Subject "yeast phenotypes"
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Item Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes(Genome Biology, 2007-12-05) McGary, Kriston L.; Lee, Insuk; Marcotte, Edward M.We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org webcite.