Browsing by Subject "hybrid"
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Item Building a hybrid modular polyketide synthase to investigate ketosynthase selectivity(2023) Annaswamy, Shreyas; Keatinge-Clay, AdrianPolyketides are a diverse class of molecules which are biosynthesized in many different organisms, such as bacteria, fungi, plants, and animals. They are biologically active compounds and are often harnessed for pharmacological purposes. These natural products are synthesized by large enzyme complexes called polyketide synthases (PKSs), which are comprised of various domains, such as the acyltransferase (AT) and ketosynthase (KS), that each perform a specific chemical modification to build and process the polyketide. Type 1 modular PKSs in particular are organized into several modules, each containing different sets of domains, which act in an assembly line fashion to add extender units to a starter unit, shuttling the intermediates between the modules with the help of the acyl carrier protein (ACP). Upon reaching the final module, the product either cyclizes or dissociates for further processing (such as glycosylation).Item Fabrication and Characterization of Ti6Al4V by Selective Electron Beam and Laser Hybrid Melting(University of Texas at Austin, 2017) Zhou, Bin; Zhou, Jun; Li, Hongxin; Lin, FengA hybrid process, which combines electron beam selective melting(EBSM) and selective laser melting(SLM), is proposed in this study. Laser is led into the vacuum chamber through the lens so that laser can be used to fabricate the metal powder at the same time with electron beam. In this study, Laser is used to pre-preheat the metal powder in order to preventing powder spreading and laser is also used to fabricate the contour of the parts both inside and outside. Electron beam is used to preheat the metal powder to the specified temperature and to fabricate the interior of the parts. It can be sure that through the hybrid process we can fabricate the parts with both better surface quality, higher precision and higher efficiency. Ti6Al4V samples were fabricated by selective electron beam and laser hybrid melting. The surface roughness of the parts was measured, the microstructures of the contour and interior were characterized using scanning electron microscopy (SEM). The results are that as-fabricated parts have better surface quality than the parts fabricated only using EBM process.Item Finite Element Modeling of Hybrid Additive Manufacturing by Laser Shock Peening(University of Texas at Austin, 2016) Sealy, M.P.; Madireddy, G.; Li, C.; Guo, Y.B.Hybrid manufacturing has traditionally targeted efficiency and productivity as improvement criteria. However, the advent of additive manufacturing to print functional parts has expanded the possibilities for a hybrid approach in this field. Hybrid additive manufacturing is the combination of two or more manufacturing processes or materials that synergistically affect the quality and performance of a printed part. Hybrid additive manufacturing allows for advancements in material properties beyond efficiency and productivity. Mechanical, physical, and chemical properties can be designed and printed. The purpose of this study was to model a hybrid additive manufacturing process to investigate the resulting mechanical properties. Laser shock peening (LSP) was coupled with selective laser melting in a 2D finite element simulation in Abaqus to quantify the resulting residual stress fields. The effects of peak pressure and layer thickness were studied when coupling laser shock peening with selective laser melting.