Browsing by Subject "antivirals"
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Item Distinct Antiviral Responses in Pluripotent versus Differentiated Cells(PLOS Pathogens, 2014-02-06) Pare, Justin M.; Sullivan, Christopher S.There is a mystery unfolding, the solution of which has implications for the understanding of both stem cell biology and the evolution of the vertebrate pathogen defense response. At the heart of this puzzle lies the observation of substantially different antiviral responses in mammalian cells with high potency (e.g., embryonic stem, oocytes, induced pluripotent, teratocarcinoma, and embryonic carcinoma cells) versus differentiated somatic cells (i.e., epithelial, fibroblast, lymphocyte). While differentiated cells are proficient in the interferon (IFN)-associated protein-based response [1]–[3], pluripotent cells have an attenuated IFN response [4]–[8]. Conversely, pluripotent cells can utilize RNA interference (RNAi) to combat viruses [9], [10], while this response is attenuated in differentiated cells [11]. Here we provide an overview of this developing area of virology.Item Optimizing Spatiotemporal Antiviral Release Schedules in a Pandemic Influenza(2015-08-12) Singh, BismarkTo help the state of Texas plan pandemic influenza interventions, we build a stochastic mixed-integer program to compute time-based antiviral releases. We can derive millions of scenarios in the stochastic program from an epidemic simulator that accounts for large amount of uncertainty in the disease progression. We study techniques to solve this problem, as a direct-solve is intractable.