Now showing items 1-2 of 2
Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans
(Public Library of Science, 2011-10-13)
In eukaryotes, gene expression is a complex, multi-step process involving transcription, splicing, translation, and post-translational modifications. At each individual step, errors can occur that lead to nonfunctional and ...
Extensive Evolutionary Changes in Regulatory Element Activity during Human Origins Are Associated with Altered Gene Expression and Positive Selection
(Public Library of Science, 2012-06-28)
Understanding the molecular basis for phenotypic differences between humans and other primates remains an outstanding challenge. Mutations in non-coding regulatory DNA that alter gene expression have been hypothesized as ...