Fabrication and Characterization of Electrospun Drug-eluting Nanofibers from Polycaprolactone/Chitosan Blends

Date

2019-04

Authors

Thompson, Jeffrey
Gizaw, Mulugeta
Chou, Shih-Feng

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Engineering Education

Abstract

Electrospinning has emerged as a widely accepted technique with ability to produce nanofibers that can be employed in many biomedical applications. In particular, drug-eluting nanofibers have become very popular in controlled release of small molecule drugs. In this study, nanofibers from blends of polylactocaprone (PCL) and chitosan (CHI) were electrospun with the ability to load a model drug, acetylsalicylic acid (ASA), at 10 wt%. PCL/CHI fibers exhibited smooth surface morphology at polymer compositions ranging from 100/0 to 40/60 with or without the incorporation of ASA. Mechanical properties suggested a brittle failure mechanism for fibers loaded with drug. In vitro drug release study displayed a controlled release profile of ASA up to 48 h. Our study aims to explore the drug-polymer interactions and their effects on fiber structure, mechanical properties and drug release profile.

Description

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Citation

Thompson, J., & Gizaw, M., & Chou, S. (2019, April), Fabrication and Characterization of Electrospun Drug-eluting Nanofibers from Polycaprolactone/Chitosan Blends Paper presented at 2018 ASEE Gulf-Southwest Section Annual Meeting, AT&T Executive Education and Conference Center, Austin, TX 78705. https://peer.asee.org/31611