1,2-diaminocyclohexane-platinum complexes with antitumor activity

dc.contributor.assigneeBoard of Regents, Univ. of Tex. Sys.
dc.creatorKhokhar, Abdul R.
dc.creatorNewman, Robert A. III
dc.creatorKrakoff, Irwin H.
dc.date.accessioned2019-05-14T14:33:32Z
dc.date.available2019-05-14T14:33:32Z
dc.date.filed1991-04-30
dc.date.issued1991-04-30
dc.description.abstractThe present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula: EQU trans-R,R-DACH Pt(II) X.sub.2 or EQU trans-R,R-DACH Pt(II) Y wherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH. In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula: EQU trans-R,R-DACH Pt(II) X.sub.2 wherein X is a monovalent cation. Two X substituents are present in the platinum complex. These X substituents are preferably selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethylglycinato. Both X substituents are usually identical butmay be different.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber6932176
dc.identifier.patentnumber5011959
dc.identifier.urihttps://hdl.handle.net/2152/74600
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/1718
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.subject.cpcC07H23/00
dc.subject.cpcC07F15/0093
dc.subject.uspc127/29
dc.subject.uspc127/30
dc.subject.uspc514/23
dc.subject.uspc514/184
dc.subject.uspc514/492
dc.subject.uspc549/206
dc.subject.uspc556/137
dc.title1,2-diaminocyclohexane-platinum complexes with antitumor activity
dc.typePatent

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