Calorie restriction and cancer prevention: a mechanistic perspective

dc.creatorHursting, Stephen D.en
dc.creatorDunlap, Sarah M.en
dc.creatorFord, Nikki A.en
dc.creatorHursting, Marcie J.en
dc.creatorLashinger, Laura M.en
dc.descriptionStephen D Hursting12*, Sarah M Dunlap1, Nikki A Ford1, Marcie J Hursting3 and Laura M Lashinger12 Author Affiliations 1 Department of Nutritional Sciences, The University of Texas at Austin, 1400 Barbara Jordan Blvd, DPRI 2.834, Austin, TX, 78723, USA 2 Department of Molecular Carcinogenesis, The University of Texas-MD Anderson Cancer Center, Smithville, TX, USA 3 Clinical Science Consulting, Austin, TX, USAen
dc.description.abstractCalorie restriction (CR) is one of the most potent broadly acting dietary interventions for inducing weight loss and for inhibiting cancer in experimental models. Translation of the mechanistic lessons learned from research on CR to cancer prevention strategies in human beings is important given the high prevalence of excess energy intake, obesity, and metabolic syndrome in many parts of the world and the established links between obesity-associated metabolic perturbations and increased risk or progression of many types of cancer. This review synthesizes findings on the biological mechanisms underlying many of the anticancer effects of CR, with emphasis on the impact of CR on growth factor signaling pathways, inflammation, cellular and systemic energy homeostasis pathways, vascular perturbations, and the tumor microenvironment. These CR-responsive pathways and processes represent targets for translating CR research into effective cancer prevention strategies in human beings.en
dc.description.departmentNutritional Sciencesen
dc.identifier.citationHursting, Stephen D., Sarah M. Dunlap, Nikki A. Ford, Marcie J. Hursting, and Laura M. Lashinger. “Calorie Restriction and Cancer Prevention: A Mechanistic Perspective.” Cancer and Metabolism 1, no. 1 (March 7, 2013): 10. doi:10.1186/2049-3002-1-10.en
dc.publisherCancer and Metabolismen
dc.rightsAdministrative deposit of works to UT Digital Repository: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access at The public license is specified as CC-BY: The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.subjectCalorie restrictionen
dc.subjectCancer preventionen
dc.subjectGrowth factorsen
dc.subjectInflammation; Metabolismen
dc.titleCalorie restriction and cancer prevention: a mechanistic perspectiveen

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