Acetic acid as a contrast in reflectance confocal imaging of tissue

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Date

2001-02-13

Authors

Rebecca R. Richards-Kortum
Rebekah Drezek
Colin L. Smithpeter
Andres Zuluaga

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United States Patent and Trademark Office

Abstract

A method for using acetic acid as a contrast agent during reflectance confocal imaging of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of using acetic acid as a contrast agent for confocal imaging of cells, including applying acetic acid to the diagnostic tissue sample in sufficient concentration to induce a small scale alteration of the index of refraction of nuclei in the cells; and imaging such cells using a reflectance confocal imaging system.

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