Drosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signaling

dc.creatorLee, Ji-Hoonen
dc.creatorFischer, Janice A.en
dc.date.accessioned2013-05-23T16:30:13Zen
dc.date.available2013-05-23T16:30:13Zen
dc.date.issued2012-09-28en
dc.description.abstractTel2, a protein conserved from yeast to vertebrates, is an essential regulator of diverse cellular processes including telomere maintenance, DNA damage checkpoints, DNA repair, biological clocks, and cell signaling. The Drosophila Tel2 protein is produced as a translational fusion with EpsinR, a Clathrin adapter that facilitates vesicle trafficking between the Golgi and endosomes. EpsinR and Tel2 are encoded by a Drosophila gene called lqfR. lqfR is required for viability, and its specific roles include cell growth, proliferation, and planar cell polarity. We find that all of these functions of lqfR are attributed entirely to Tel2, not EpsinR. In addition, we find that Drosophila LqfR/Tel2 is a component of one or more protein complexes that contain E-cadherin and Armadillo. Moreover, Tel2 modulates E-cadherin and Armadillo cellular dynamics. We propose that at least one of the functions of Drosophila Tel2 is regulation of Wingless signaling.en
dc.description.departmentCellular and Molecular Biologyen
dc.description.sponsorshipThis work was supported by the National Institute of Child Health and Human Development (NICHD) Grant RO1-HD30680. The funders had no role in study design, data collection and alaysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationLee J-H, Fischer JA (2012) Drosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signaling. PLoS ONE 7(9): e46357. doi:10.1371/journal.pone.0046357en
dc.identifier.doi10.1371/journal.pone.0046357en
dc.identifier.urihttp://hdl.handle.net/2152/20158en
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.rightsCC-BYen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.subjectArmadillosen
dc.subjectDrosophilaen
dc.subjectEyesen
dc.subjectGene expressionen
dc.subjectMembrane proteinsen
dc.subjectMutationen
dc.subjectPhenotypesen
dc.subjectProtein expressionen
dc.titleDrosophila Tel2 Is Expressed as a Translational Fusion with EpsinR and Is a Regulator of Wingless Signalingen
dc.typeArticleen
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
journal.pone.0046357.pdf
Size:
4.6 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
admin_deposit_plosone.pdf
Size:
69.18 KB
Format:
Adobe Portable Document Format
Description:
Administrative Deposit