Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response

dc.creatorIlango, Antonen
dc.creatorShumake, Jasonen
dc.creatorWetsel, Wolframen
dc.creatorScheich, Henningen
dc.creatorOhl, Frank W.en
dc.date.accessioned2014-12-15T17:10:39Zen
dc.date.available2014-12-15T17:10:39Zen
dc.date.issued2013-06-28en
dc.descriptionAnton Ilango, Jason Shumake, Wolfram Wetzel, Henning Scheich, Frank W. Ohl, Department Systems physiology of learning, Leibniz Institute for Neurobiology, Magdeburg, Germanyen
dc.descriptionFrank W. Ohl, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germanyen
dc.descriptionJason Shumake, Department of Psychology, The University of Texas, Austin, Texas, United States of Americaen
dc.descriptionHenning Scheich, Frank W. Ohl, Center for Behavioral Brain Science, Otto-von-Guericke University, Magdeburg, Germanyen
dc.description.abstractThe lateral habenula (LHb) is an epithalamic structure involved in signaling reward omission and aversive stimuli, and it inhibits dopaminergic neurons during motivated behavior. Less is known about LHb involvement in the acquisition and retrieval of avoidance learning. Our previous studies indicated that brief electrical stimulation of the LHb, time-locked to the avoidance of aversive footshock (presumably during the positive affective “relief” state that occurs when an aversive outcome is averted), inhibited the acquisition of avoidance learning. In the present study, we used the same paradigm to investigate different frequencies of LHb stimulation. The effect of 20 Hz vs. 50 Hz vs. 100 Hz stimulation was investigated during two phases, either during acquisition or retrieval in Mongolian gerbils. The results indicated that 50 Hz, but not 20 Hz, was sufficient to produce a long-term impairment in avoidance learning, and was somewhat more effective than 100 Hz in this regard. None of the stimulation parameters led to any effects on retrieval of avoidance learning, nor did they affect general motor activity. This suggests that, at frequencies in excess of the observed tonic firing rates of LHb neurons (>1–20 Hz), LHb stimulation may serve to interrupt the consolidation of new avoidance memories. However, these stimulation parameters are not capable of modifying avoidance memories that have already undergone extensive consolidation.en
dc.description.catalogingnoteEmail: frank.ohl@lin-magdeburg.deen
dc.description.departmentPsychologyen
dc.description.sponsorshipThe study was supported by grants from the Deutsche Forschungsgemeinschaft DFG (SFB 779, SFB-TRR-62) and from the Center for Behavioral Brain Research (CBBS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.Filenamejournal.pone.0065684.pdfen
dc.identifier.citationIlango A, Shumake J, Wetzel W, Scheich H, Ohl FW (2013) Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response. PLoS ONE 8(6): e65684. doi:10.1371/journal.pone.0065684en
dc.identifier.doiDOI: 10.1371/journal.pone.0065684en
dc.identifier.urihttp://hdl.handle.net/2152/27913en
dc.language.isoEnglishen
dc.publisherPLOS Oneen
dc.rightsAdministrative deposit of works to UT Digital Repository: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access at http://www.plosone.org. The public license is specified as CC-BY: http://creativecommons.org/licenses/by/4.0/. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.subjectbehavioren
dc.subjectdopamineen
dc.subjectdopaminergicsen
dc.subjectelectrical stimulationsen
dc.subjecthuman learningen
dc.subjectlearningen
dc.subjectmotivationen
dc.subjectnueronsen
dc.titleElectrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Responseen
dc.typeArticleen

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