A self-degradable hydrogel sensor for a nerve agent tabun surrogate through a self-propagating cascade

dc.creatorLee, Doo-Hee
dc.creatorValenzuela, Stephanie A.
dc.creatorDominguez, Manuel N.
dc.creatorOtsuka, Mai
dc.creatorMilliron, Delia J.
dc.creatorAnslyn, Eric V.
dc.date.accessioned2024-02-08T17:35:56Z
dc.date.available2024-02-08T17:35:56Z
dc.date.issued2021-09-22
dc.description.abstractNerve agents that irreversibly deactivate the enzyme acetylcholin- esterase are extremely toxic weapons of mass destruction. Thus, developing methods to detect these lethal agents is important. To create an optical sensor for a surrogate of the nerve agent tabun, as well as a physical barrier that dissolves in response to this analyte, we devise a network hydrogel that decomposes via a self-propagating cascade. A Meldrums acid-derived linker is incor- porated into a hydrogel that undergoes a declick reaction in response to thiols, thereby breaking network connections, which re- leases more thiols, propagating the response throughout the gel. A combination of chemical reactions triggered by the addition of the tabun mimic initiates the cascade. The dissolving barrier is used to release dyes, as well as nanocrystals that undergo a spontaneous aggregation. Thus, this sensing system for tabun generates a phys- ical response and the delivery of chemical agents in response to an initial trigger.
dc.description.departmentCenter for Dynamics and Control of Materials
dc.description.sponsorshipThis work was supported primarily by the National Science Foundation (NSF) through the Center for Dynamics and Control of Materials: an NSF Materials Research Science and Engineering Center (MRSEC) under Cooperative Agreement DMR-1720595 and NMR instruments obtained through NIH grant 1 S10 OD021508- 01. For this project, S.A.V. received funding from the NSF Graduate Research Fellowship Program (DGE-1610403). Additional funding for this project came from the Welch Foundation (F-1848 and F-1696). E.V.A. acknowledges support from the Welch Regents Chair (F-0046). D.-H.L. acknowledges support from ROKA. M.O. received support from the Japan Society for the Promotion of Science (JSPS) Overseas Challenge Program for Young Researchers.
dc.identifier.citationLee, DH; Valenzuela, SA; Dominguez, MN; Otsuka, M; Milliron, DJ; Anslyn, EV. A self-degradable hydrogel sensor for a nerve agent tabun surrogate through a self-propagating cascade. Cell Rep. Phys. Sci. 2021, 2(9), 100552-. DOI: 10.1016/j.xcrp.2021.100552 .
dc.identifier.doiDOI: 10.1016/j.xcrp.2021.100552
dc.identifier.urihttps://hdl.handle.net/2152/123637
dc.identifier.urihttps://doi.org/10.26153/tsw/50431
dc.language.isoen_US
dc.publisherElsevier
dc.relation.ispartofCenter for Dynamics and Control of Materials Publications
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United Statesen
dc.rights.restrictionOpen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/
dc.subjectHydrogels
dc.titleA self-degradable hydrogel sensor for a nerve agent tabun surrogate through a self-propagating cascade
dc.typeArticle
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