Conservation and comparison of protein interactions across evolution

dc.contributor.advisorMarcotte, Edward M.
dc.contributor.committeeMemberBrowning, Karen
dc.contributor.committeeMemberCambronne, Xiaolu Lulu
dc.contributor.committeeMemberWallingford, John
dc.contributor.committeeMemberWilke, Claus
dc.creatorMcWhite, Claire Darnell
dc.creator.orcid0000-0001-7346-3047
dc.date.accessioned2020-09-03T20:22:14Z
dc.date.available2020-09-03T20:22:14Z
dc.date.created2020-05
dc.date.issued2020-05
dc.date.submittedMay 2020
dc.date.updated2020-09-03T20:22:14Z
dc.description.abstractWe share core molecular systems with organisms across the tree of life. Though studying multiple organisms at once, we can find biological signals that rise above experimental noise. Comparative evolutionary analysis is an approach that combines evolutionary and systems biology, in essence, a parallel assay where each organism is a data point. Repeated observation of a feature across multiple organisms increases confidence that the signal reflects biology. However, integrating data from different species adds a layer of complexity to high-throughput analysis. In this dissertation, I will first present a review of the use of comparative evolution in human disease genetics, then a characterization and comparison of different orthology algorithms, and finally the culmination of this work of a high-throughput discovery of stable protein complexes conserved across plants.
dc.description.departmentCellular and Molecular Biology
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/82735
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/9737
dc.language.isoen
dc.subjectComparative evolution
dc.subjectProteomics
dc.subjectProtein complexes
dc.titleConservation and comparison of protein interactions across evolution
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentCellular and Molecular Biology
thesis.degree.disciplineCell and Molecular Biology
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy
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