Formation of stable submicron peptide or protein particles by thin film freezing

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dc.contributor.assigneeBoard of Regents, The University of Texas System
dc.creatorRobert O. Williams, III
dc.creatorKeith P. Johnston
dc.creatorJoshua Engstrom
dc.date.accessioned2019-10-23T14:33:09Z
dc.date.available2019-10-23T14:33:09Z
dc.date.filed2008-06-20
dc.date.issued2015-03-03
dc.description.abstractThe present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
dc.description.departmentBoard of Regents, University of Texas System
dc.identifier.applicationnumber12665386
dc.identifier.patentnumber8968786
dc.identifier.urihttps://hdl.handle.net/2152/76651
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/3740
dc.publisherUnited States Patent and Trademark Office
dc.relation.ispartofUniversity of Texas Patents
dc.relation.ispartofUniversity of Texas Patents
dc.rights.restrictionOpen
dc.rights.restrictionOpen
dc.subject.cpcA61K9/1682
dc.subject.cpcA61K9/1658
dc.subject.cpcB01D9/005
dc.subject.cpcY10T428/2982
dc.subject.uspc424/489
dc.subject.uspc514/15.2
dc.titleFormation of stable submicron peptide or protein particles by thin film freezing
dc.typePatent

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