Formation of stable submicron peptide or protein particles by thin film freezing

Access full-text files

Date

2015-03-03

Authors

Robert O. Williams, III
Keith P. Johnston
Joshua Engstrom

Journal Title

Journal ISSN

Volume Title

Publisher

United States Patent and Trademark Office

Abstract

The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.

Description

Keywords

LCSH Subject Headings

Citation