Development of microphysiological human intestine models for deciphering the role of host-gut microbiome crosstalk in intestinal diseases

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dc.contributor.advisorKim, Hyun Jung (Biomedical engineering researcher)
dc.contributor.committeeMemberCossgriff-Hernandez, Elizabeth
dc.contributor.committeeMemberEckhardt, S. Gail
dc.contributor.committeeMemberKim, YongTae
dc.contributor.committeeMemberSuggs, Laura J.
dc.creatorShin, Woojung
dc.creator.orcid0000-0002-1780-0317
dc.date.accessioned2022-10-01T17:50:58Z
dc.date.available2022-10-01T17:50:58Z
dc.date.created2020-08
dc.date.issued2020-09-04
dc.date.submittedAugust 2020
dc.date.updated2022-10-01T17:50:59Z
dc.description.abstractThe human microbiome and its crosstalk with host cells play a critical role in regulating human health and disease. However, the underlying mechanism of how the host-microbiome crosstalk affects the disease etiology remains largely elusive, mainly because of a lack of reliable model systems. It has been demonstrated that the microphysiological human gut-on-a-chip system enables to stably co-culture the living human microbiome under the physiologically relevant tissue microarchitecture and biomechanical cues to recapitulate complex crosstalk in the epithelium-microbiome-immune axis in the intestinal microenvironment. By leveraging this innovative technology, the mechanistic investigation of epithelial morphogenesis, the establishment of a novel platform to co-culture anaerobic bacteria, the identification of the etiological trigger in the intestinal inflammation, and the development of patient-specific intestinal disease models by integrating patient’s samples have been performed. The development and utilization of the microphysiological human intestine models can potentially produce disseminating impacts to deciphering the host-microbiome crosstalk in gastrointestinal diseases
dc.description.departmentBiomedical Engineering
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2152/116036
dc.identifier.urihttp://dx.doi.org/10.26153/tsw/42932
dc.language.isoen
dc.subjectMicrophysiological system
dc.subjectGut-on-a-chip
dc.subjectHost-microbiome crosstalk
dc.subjectMicroengineered intestine model
dc.subjectIntestinal disease model
dc.titleDevelopment of microphysiological human intestine models for deciphering the role of host-gut microbiome crosstalk in intestinal diseases
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentBiomedical Engineering
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

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