Enhanced delivery of drug compositions to treat life threatening infections
Access full-text files
Date
2017-08-08
Authors
Robert O. Williams, III
Christopher J. Tucker
Keith P. Johnston
James E. Hitt
Brian D. Scherzer
Timothy J. Young
True L. Rogers
David A. Hayes
David S. Burgess
Jason T. McConville
Journal Title
Journal ISSN
Volume Title
Publisher
United States Patent and Trademark Office
Abstract
Inhalable compositions are described. The inhalable compositions comprise one or more respirable aggregates, the respirable aggregates comprising one or more poorly water soluble active agents, wherein at least one of the active agents reaches a maximum lung concentration (Cmax) of at least about 0.25 μg/gram of lung tissue and remains at such concentration for a period of at least one hour after being delivered to the lung. Methods for making such compositions and methods for using such compositions are also disclosed.