Liposome-mediated transfection of central nervous system cells

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Date

2000-08-01

Authors

Hayes, Ronald L.
Yang, Keyi
Faustinella, Fabrizia

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United States Patent and Trademark Office

Abstract

Disclosed are methods for use in transferring nucleic acids into central nervous system cells in vivo and in vitro and/or for stimulating central nervous system cells. Neurotrophic genes are shown to stimulate neurofilament cells and to promote nerve cell growth, repair and regeneration in vivo. Gene transfer protocols are disclosed for use in transferring various nucleic acid materials into central nervous system cells, as may be used in treating various pathologies of the brain and spinal cord.

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