Adhesion promotes phase separation in mixed-lipid membranes

dc.creatorGordon, Vernita D.en
dc.creatorDeserno, M.en
dc.creatorAndrew, C. M. J.en
dc.creatorEgelhaaf, S. U.en
dc.creatorPoon, W. C. K.en
dc.date.accessioned2014-09-29T18:06:39Zen
dc.date.available2014-09-29T18:06:39Zen
dc.date.issued2008-11en
dc.descriptionV.D. Gordon (currently with UT Austin), C.M.J. Andrew, S.U. Egelhaaf, and W.C. K. Poon are with SUPA, School of Physics, and COSMIC, The University of Edinburgh – M. Desserno is with the Max-Planck-Institut f¨ur Polymerforschung and the Department of Physics, Carnegie Mellon University – S.U. Egelhaaf is with the Condensed Matter Physics Laboratory, Heinrich-Heine-Universityen
dc.description.abstractWe investigate the interplay of domain formation and adhesion in mixed-lipid membranes. Giant unilamellar vesicles consisting of two- and three-component lipid mixtures are studied using confocal fluorescence microscopy. Upon driving the system towards the demixing transition, phase separation is invariably found to occur first in regions where membranes adhere to one another, despite identical lipid headgroups and negligible curvature effects. We propose a simple generic mechanism based on the suppression of thermal shape fluctuations to explain these observations. Our findings suggest novel possibilities by which biomembranes can create and utilize lateral lipid heterogeneities.en
dc.description.departmentChemistryen
dc.identifier.citationGordon, V. D., M. Deserno, C. M. J. Andrew, S. U. Egelhaaf, and W. C. K. Poon. “Adhesion Promotes Phase Separation in Mixed-Lipid Membranes.” EPL (Europhysics Letters) 84, no. 4 (November 1, 2008): 48003. doi:10.1209/0295-5075/84/48003.en
dc.identifier.urihttp://hdl.handle.net/2152/26166en
dc.language.isoengen
dc.publisherEuropean Physical Societyen
dc.relation.ispartofseriesEPL (Europhysics Letters) 84;no. 4en
dc.subjectAdhesionen
dc.subjectphase separationen
dc.subjectmixed-lipid membranesen
dc.subjectmicroscopyen
dc.subjectthermal shape fluctuationsen
dc.subjectbiomembranesen
dc.subjectlateral lipid heterogeneitiesen
dc.titleAdhesion promotes phase separation in mixed-lipid membranesen
dc.typeArticleen
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