Development Of Caspofungin Resistance Following Prolonged Therapy For Invasive Candidiasis Secondary To Candida Glabrata Infection

Date

2008-10

Authors

Thompson, George R.
Wiederhold, Nathan P.
Vallor, Ana C.
Villareal, Nyria C.
Lewis, James S.
Patterson, Thomas F.

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Abstract

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

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Citation

Thompson, G. R., Wiederhold, N. P., Vallor, A. C., Villareal, N. C., Lewis, J. S., & Patterson, T. F. (Oct., 2008). Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection. Antimicrobial Agents and Chemotherapy, 52(10), 3783–3785. doi:10.1128/AAC.00473-08