Overcoming antibiotic resistance in microbial populations : an interdisciplinary perspective

dc.contributor.advisorGordon, Vernita Diane
dc.creatorKaushik, Karishma Surendra
dc.creator.orcid0000-0001-5131-1798
dc.date.accessioned2017-05-05T16:13:20Z
dc.date.available2017-05-05T16:13:20Z
dc.date.issued2015-08
dc.date.submittedAugust 2015
dc.date.updated2017-05-05T16:13:20Z
dc.description.abstractAntibiotic resistance is a major public health problem. The increase in antibiotic-resistant bacteria and decline in the approval of newer antibiotics has prompted the need for novel therapeutic approaches. In the environment and in the human body, microbes are exposed to varying spatial landscapes. Further, bacteria assemble into multicellular assemblies called biofilms, which possess intricate spatial structure. Inherent to this spatial structure, microbial communities also possess population structure, characterized by cell density, spatial organization, and different cell types. This dissertation has three main goals: i) to study the effect of microbial population structure on the survival of antibiotic resistant mutants, using P. aeruginosa, an opportunistic human pathogen as a model organism, ii) to evaluate the therapeutic potential of using bicarbonate to enhance the efficacy of aminoglycoside antibiotics, first-line agents for P. aeruginosa infections, and develop an improved method of analysis of drug interactions iii) to develop a low-cost, hands-on, educational module to characterize antimicrobial compounds using an interdisciplinary, biophysical approach.
dc.description.departmentMicrobiology
dc.format.mimetypeapplication/pdf
dc.identifierdoi:10.15781/T22F7JX0J
dc.identifier.urihttp://hdl.handle.net/2152/46732
dc.language.isoen
dc.subjectAntibiotic resistance
dc.subjectPseudomonas aeruginosa
dc.subjectBiophysics
dc.subjectAntibiotic-resistant bacteria
dc.subjectMicrobial communities
dc.subjectBiofilms
dc.subjectMicrobial population
dc.subjectP. aeruginosa
dc.subjectAminoglycoside antibiotics
dc.subjectDrug interaction analysis
dc.subjectInterdisciplinary
dc.titleOvercoming antibiotic resistance in microbial populations : an interdisciplinary perspective
dc.typeThesis
dc.type.materialtext
thesis.degree.departmentMicrobiology
thesis.degree.disciplineMicrobiology
thesis.degree.grantorThe University of Texas at Austin
thesis.degree.levelDoctoral
thesis.degree.nameDoctor of Philosophy

Access full-text files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
KAUSHIK-DISSERTATION-2015.pdf
Size:
24.86 MB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.85 KB
Format:
Plain Text
Description: