Simulating school closure policies for cost effective pandemic decision making

dc.creatorAraz, Ozugr M.en
dc.creatorDamien, Paulen
dc.creatorPaltiel, David A,en
dc.creatorBurke, Seanen
dc.creatorvan de Geijn, Bryceen
dc.creatorGalvani, Alisonen
dc.creatorMeyers, Lauren Ancelen
dc.date.accessioned2014-12-15T17:09:39Zen
dc.date.available2014-12-15T17:09:39Zen
dc.date.issued2012-06-18en
dc.descriptionOzgur M. Araz is with the College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA -- Paul Damien is with the Information, Risk, and Operations Management Department, McCombs School of Business, The University of Texas, Austin, TX, 78712, USA -- David A. Paltiel and Alison Galvani are witht the School of Medicine, Yale University, CT, New Haven, 06510, USA -- Sean Burke, Bryce van de Geijn and Lauren Ancel Meyers are with the Section of Integrative Biology, The University of Texas at Austin, Austin, TX, 78712, USA -- Alison Galvani is with the Epidemiology and Public Health, New Haven, CT, 06510, USA -- Lauren Ancel Meyers is with the Santa Fe Institute, Santa Fe, NM, USAen
dc.description.abstractBackground: Around the globe, school closures were used sporadically to mitigate the 2009 H1N1 influenza pandemic. However, such closures can detrimentally impact economic and social life. Methods: Here, we couple a decision analytic approach with a mathematical model of influenza transmission to estimate the impact of school closures in terms of epidemiological and cost effectiveness. Our method assumes that the transmissibility and the severity of the disease are uncertain, and evaluates several closure and reopening strategies that cover a range of thresholds in school-aged prevalence (SAP) and closure durations. Results: Assuming a willingness to pay per quality adjusted life-year (QALY) threshold equal to the US per capita GDP ($46,000), we found that the cost effectiveness of these strategies is highly dependent on the severity and on a willingness to pay per QALY. For severe pandemics, the preferred strategy couples the earliest closure trigger (0.5% SAP) with the longest duration closure (24 weeks) considered. For milder pandemics, the preferred strategies also involve the earliest closure trigger, but are shorter duration (12 weeks for low transmission rates and variable length for high transmission rates). Conclusions: These findings highlight the importance of obtaining early estimates of pandemic severity and provide guidance to public health decision-makers for effectively tailoring school closures strategies in response to a newly emergent influenza pandemic.en
dc.description.catalogingnoteozgur.araz@unmc.eduen
dc.description.departmentInformation, Risk, and Operations Management (IROM)en
dc.description.departmentIntegrative Biologyen
dc.description.sponsorshipen
dc.identifier.Filename1471-2458-12-449.pdfen
dc.identifier.citationAraz, Ozgur M., Paul Damien, David A. Paltiel, Sean Burke, Bryce van de Geijn, Alison Galvani, and Lauren A. Meyers. “Simulating School Closure Policies for Cost Effective Pandemic Decision Making.” BMC Public Health 12, no. 1 (June 18, 2012): 449. doi:10.1186/1471-2458-12-449.en
dc.identifier.doidoi:10.1186/1471-2458-12-449en
dc.identifier.urihttp://hdl.handle.net/2152/27783en
dc.language.isoEnglishen
dc.publisherBMC Public Healthen
dc.rightsAdministrative deposit of works to UT Digital Repository: This works author(s) is or was a University faculty member, student or staff member; this article is already available through open access at http://www.biomedcentral.com. The public license is specified as CC-BY: http://creativecommons.org/licenses/by/4.0/. The library makes the deposit as a matter of fair use (for scholarly, educational, and research purposes), and to preserve the work and further secure public access to the works of the University.en
dc.subjectschool closuresen
dc.subjectpandemic decision makingen
dc.subjectinfluenzaen
dc.titleSimulating school closure policies for cost effective pandemic decision makingen
dc.typeArticleen

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