Potential for Rabies Control through Dog Vaccination in Wildlife-Abundant Communities of Tanzania

dc.creatorFitzpatrick, Meagan C.en
dc.creatorHampson, Katieen
dc.creatorCleaveland, Sarahen
dc.creatorMeyers, Lauren Ancelen
dc.creatorTownsend, Jeffrey P.en
dc.creatorGalvani, Alison P.en
dc.descriptionMeagan C. Fitzpatrick is with Yale University, Katie Hampson is with University of Glasgow, Sarah Cleaveland is with University of Glasgow, Lauren Ancel Meyers is with UT Austin and the Santa Fe Institute, Jeffrey P. Townsend is with Yale University, Alison P. Galvani is with Yale University.en
dc.description.abstractCanine vaccination has been successful in controlling rabies in diverse settings worldwide. However, concerns remain that coverage levels which have previously been sufficient might be insufficient in systems where transmission occurs both between and within populations of domestic dogs and other carnivores. To evaluate the effectiveness of vaccination targeted at domestic dogs when wildlife also contributes to transmission, we applied a next-generation matrix model based on contract tracing data from the Ngorongoro and Serengeti Districts in northwest Tanzania. We calculated corresponding values of R0, and determined, for policy purposes, the probabilities that various annual vaccination targets would control the disease, taking into account the empirical uncertainty in our field data. We found that transition rate estimates and corresponding probabilities of vaccination-based control indicate that rabies transmission in this region is driven by transmission within domestic dogs. Different patterns of rabies transmission between the two districts exist, with wildlife playing a more important part in Ngorongoro and leading to higher recommended coverage levels in that district. Nonetheless, our findings indicate that an annual dog vaccination campaign achieving the WHO-recommended target of 70% will control rabies in both districts with a high level of certainty. Our results support the feasibility of controlling rabies in Tanzania through dog vaccination.en
dc.description.departmentBiological Sciences, School ofen
dc.description.sponsorshipMCF and APG were funded by National Institutes of Health grant U01 GM087719, Models of Infectious Disease Agent Study (MIDAS), and KH was funded by the Wellcome Trust. Field data were generated with the support of the National Science Foundation and NIH (DEB0225453, DEB0513994), the Wellcome Trust, and Lincoln Park Zoo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationFitzpatrick MC, Hampson K, Cleaveland S, Meyers LA, Townsend JP, et al. (2012) Potential for Rabies Control through Dog Vaccination in Wildlife-Abundant Communities of Tanzania. PLoS Negl Trop Dis 6(8): e1796. doi:10.1371/journal.pntd.0001796en
dc.publisherPublic Library of Scienceen
dc.rightsAttribution 3.0 United Statesen
dc.subjectDomestic animalsen
dc.subjectInfectious disease epidemiologyen
dc.subjectPets and companion animalsen
dc.subjectVaccination and immunizationen
dc.titlePotential for Rabies Control through Dog Vaccination in Wildlife-Abundant Communities of Tanzaniaen

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