Gels for encapsulation of biological materials

Date
1998-12-01
Authors
Jeffrey A. Hubbell
Amarpreet S. Sawhney
Neil P. Desai
Chandrashekhar P. Pathak
Jennifer L. Hill
Syed Hossainy
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United States Patent and Trademark Office
Abstract

Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

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