Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans

Date

2011-10-13

Authors

Wilke, Claus O.

Journal Title

Journal ISSN

Volume Title

Publisher

Public Library of Science

Abstract

In eukaryotes, gene expression is a complex, multi-step process involving transcription, splicing, translation, and post-translational modifications. At each individual step, errors can occur that lead to nonfunctional and potentially toxic proteins. Therefore, eukaryotes have evolved a wide array of solutions to minimize the risk of error.

Description

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Citation

Wilke CO (2011) Transcriptional Robustness Complements Nonsense-Mediated Decay in Humans. PLoS Genet 7(10): e1002296. doi:10.1371/journal.pgen.1002296